Targeted and target-activated drug delivery systems have the potential to effectively treat a variety of medical conditions, while avoiding problems such as off-site toxicity and drug resistance. This session will focus on the design and application of targeted drug delivery systems and/or drug delivery systems whose activity is triggered by the target itself (i.e. target-activated drug delivery systems). Developing these materials while promoting an appropriate immune response and maintaining biocompatibility can be challenging. Applications for such systems include but are not limited to treatments for cancer, microbial infections, cardiovascular disease, autoimmune diseases, etc. Talks in this session will range from focusing on the molecular scale design of these drug delivery systems to discussing the translational of these materials to clinical applications.