The field of orthopaedic biomaterials is driven strongly by the use of biomaterials extending from metal implants to allograft-based substitutes and synthetic and natural polymer-based scaffolds. New developments are directed toward improving cellular response, more specifically advancements that can direct cellular activity toward desired responses. One area that continues to be under investigation is the improvement of understanding corrosion of metal implants, how it progresses under in vivo loading conditions and the degradation products that are formed. Orthopaedic injuries are rarely limited to a single tissue type, but often involve tissue interfaces that present significant differences in cell type, architecture and function. The new frontiers of orthopaedics include various fronts like scaffolds that better mimic tissue interfaces (such as gradient scaffolds), new approaches to healing (such as ultrasound and growth factor incorporation. The use of synthetic and natural polymers allow for precise and tunable engineering of biodegradable implants that facilitate several regenerative requirements, such as cell delivery, controlled release of drugs (e.g., antibiotics and growth factors). The presentations cover current challenges and address new frontiers and approaches to the design, fabrication and characterization of biomaterials to improve host integration and provide instructive cues. This session will have submissions from academia, clinicians and industry, especially collaborative efforts that have identified unique challenges in the application of biomaterials in the orthopaedic field.