Engineering complex tissues that can mimic or stimulate native tissue functions hold enormous promise in treating organ failures resulting from injuries, aging, and diseases. Our inabilities to mimic complex tissue architecture and to provide an essential cellular microenvironment are some of the challenges that need to be addressed to control the formation of functional tissues. Designing multi-functional biomaterials with controlled physical, chemical, electrical and biological properties is beneficial to facilitate the formation of functional tissues. This session seeks contributions regarding new advances in functional nanomaterials with specific emphasis on emerging biomedical applications such as engineering complex tissue. In particular, contributions highlighting emerging trends in designing complex nanomaterials with multiple functionalities are encouraged. This session will primarily focus on the following topics: (1) Multifunctional nanomaterials for engineering complex tissues; (2) Emerging 2D nanomaterials for tissue engineering; (3) Micro and nano-fabricated biomaterials for drug or gene delivery; and (4) Nanotopography and stem cells.