The goal of this session is to highlight the advances and the development of biomaterials for the delivery and use of large molecules, including proteins/growth factors, nucleic acids, and viral particles. Delivery of therapeutic proteins and other biomacromolecules can be complicated by rapid degradation within tissue, uncontrolled release mechanisms, and barriers to delivery of large molecules to specific intracellular and extracellular biological targets. Topics for this session will include biomaterial platforms designed to overcome challenges in effective delivery of macromolecular therapeutics through biological targeting, extending or protecting biological activity, or controlling/triggering release. This session also invites abstracts that describe synthesis and utilization of engineered protein or nucleic acid structures as carriers for drug delivery. Across these topics, special preference will be given to abstracts focused on recent advances that promote validation and scale-up toward clinical translation.