Due to disease, degeneration, or trauma, there is a tremendous need to repair damaged tissues and organs. Although surgical replacement can be performed to address this issue, insufficient number of donors greatly limits the applicability of this approach. Therefore, it is essential to develop engineered multifunctional biomaterials to promote tissue regeneration. This symposium will cover tunable biocompatible materials such as hydrogels, fibers, proteins, carbohydrates, nano/micro-porous scaffolds, and metals, to modulate stem cell microenvironments. The biomaterials that can direct cell fate and promote differentiation will also be highlighted by this symposium. Moreover, biomaterials with the ability to facilitate small molecule delivery (e.g. drug, gene, peptide) and immunomodulation will be covered through oral and poster presentations. Furthermore, we will include discussions for the development and commercialization of various medical devices such as biosensors, blood contacting implants, prostheses, and pacemakers in the symposium. In addition to engineering approaches, we will also provide discussions on clinical translation of biomaterial-based strategies.