Cardiovascular disease is the number one cause of death globally and therefore is a major focus of regenerative engineering. Major limitations of current treatments include the lack of biomaterials with suitable chemical, physical, and biological properties, the inability to mimic tissue microarchitectures, and the availability of reliable and renewable cell sources. Promising strategies for the engineering of clinically-relevant constructs for cardiovascular regeneration include development of multifunctional biomaterials, use of nano- and micro-fabrication tools, and delivery of stem cells. These approaches have the potential to mimic native cardiac microenvironments and enable incorporation of biochemical and mechanical cues to modulate disease progression, mitigate damage, and/or promote regeneration. In this symposium, we will cover fabrication of three-dimensional cardiovascular scaffolds that are made of synthetic and natural biomaterials, vascularization of engineered cardiovascular tissues, and novel approaches for delivery of cells. This symposium will also include limitations of current engineered models of cardiovascular disease and the development alternative solutions. Finally, the symposium will also emphasize the translation of cardiovascular tissue engineering technologies from bench-to-bedside.