The field of biomaterials science has evolved from the study of biocompatible and biodegradable materials to the design of stimuli-responsive biomaterials. These materials can be programmed to respond to stimuli resulting from a variety of sources, including biomolecular recognition (e.g., peptide-, oligonucleotide-, and lipid-based interactions), chemical properties (e.g. pH and ionic strength), and physical properties (e.g. temperature). The response of the material in the presence of these stimuli can be finely tuned and may result in a change to the chemical or physical properties of the material itself (e.g. shape-memory effect). This session will highlight recent advances in designing such programmable biomaterials. Examples include but are not limited to self-assembled structures such as hydrogels, scaffolds, nanoparticles, and multilayer films. In addition to the discussion of the principles of designing such materials, the use of these programmable materials in various biomedical applications including drug delivery and tissue engineering will be presented.