Recent reports by the World Health Organization warn of an impending “post antibiotic era” in which common infections are lethal due to rising levels of antimicrobial resistance. Concurrently, there is a severe lack in development of new classes of antimicrobials. There is an immediate need to engineer advanced antimicrobial therapeutics, delivery systems, and materials that are capable of effectively combating the heterogeneous microbial populations known to cause infections. This session will focus on the development and application of these advanced antimicrobial materials targeting bacterial, fungal, and biofilm associated infections. Examples include antimicrobial implant coatings, novel antimicrobial molecules and macromolecules, antimicrobial materials for traumatic injuries, etc. Research in the design, synthesis, testing, and translation of these antimicrobial materials will be discussed.