Room 218 A/219 A

Innate Immunity and Inflammation in Biomaterials Contexts

This session focuses on topics including: understanding the first line of defense to implanted materials, the design of materials to direct innate immune function, strategies to overcome inflammation for improved outcomes in the clinical translation of biomaterials, and approaches for monitoring biomaterial/implant-associated inflammation.

Engineering Tissue Interfaces

Advances in the field of tissue engineering are increasingly reliant on biomaterials that instruct, rather than simply permit, a desired cellular response. One area of recent focus has been development of approaches to replicate or induce regenerative healing of dynamic, spatially patterned or inhomogeneous structures within the body. Such materials would have to direct the bioactivity of multiple cell types in spatially or temporally varying patterns.

Mechanical Characterization of Biomaterials

For most biomaterials, having appropriate mechanical properties is critical for their performance following implantation. For example, tissue engineering scaffolds must be design to withstand the strong forces while matching the mechanical properties of the adjacent tissues. Depending on the type of materials (e.g., ceramics and metals, hard and soft plastics, hydrogels, tissue-based), the mechanical behaviors and, thus, the methods for mechanical characterization and criteria for assessment vary significantly.

Immunomodulation in Regenerative Medicine

Biomaterials have emerged as essential tools within regenerative medicine, and it is clear that the host immune system plays a pivotal role in the success or failure of regenerative medicine strategies. This session will focus on eliciting, diminishing, or controlling immune responses in the context of biomaterials used within tissue engineering, transplantation, and regenerative medicine.

Multifunctional Nanomaterials for Engineering Complex Tissues and Drug Delivery

Engineering complex tissues that can mimic or stimulate native tissue functions hold enormous promise in treating organ failures resulting from injuries, aging, and diseases. Our inabilities to mimic complex tissue architecture and to provide an essential cellular microenvironment are some of the challenges that need to be addressed to control the formation of functional tissues. Designing multi-functional biomaterials with controlled physical, chemical, electrical and biological properties is beneficial to facilitate the formation of functional tissues.

Engineering Cells & Their Microenvironments

This session is based on the name of the special interest group (SIG) - Engineering Cells & Their Microenvironment (ECTM) and supports the translational bridge in accordance with the theme of the SFB 2015 Annual Meeting - Driving Biomaterial Innovation and the Race to Translation. Cells contain many cues in their microenvironment that need to be considered when understanding their behavior in vivo. The microenvironment contains, but is not limited to, extracellular matrix, autocrine and paracrine factors, ions, growth factors and cytokine-concentration gradients.

Characterization of Microenvironment of Immune Cells in Wound Healing

Cell-biomaterial interactions play a critical role during wound healing and new tissue formation. Wound healing involves the initial influx of immune cells such as neutrophils, macrophages, foreign body giant cells, and fibroblast. The initial upregulation of immune response to transition into complete healing involves switching of cell secretory cell types to tissue forming cells such as the fibroblast. Stem cells invade into the wound healing site as the initial influx of cells with the immune cells and guide the process of tissue formation.

Advanced Hydrogels with Hierarchal Structures for Biological Applications

Hydrogels with higher order structures are increasingly being developed for tissue engineering, drug delivery, and other biomedical applications. This session will focus on preparing advanced hydrogel systems with hierarchical structures or anisotropic properties for biological applications, including, but not limited to, directing cell-materials interactions, promoting tissue regeneration, and regulating drug delivery.