Room 213 B/C

Biomaterials for Regenerative Engineering 2

Due to disease, degeneration, or trauma, there is a tremendous need to repair damaged tissues and organs. Although surgical replacement can be performed to address this issue, insufficient number of donors greatly limits the applicability of this approach. Therefore, it is essential to develop engineered multifunctional biomaterials to promote tissue regeneration. This symposium will cover tunable biocompatible materials such as hydrogels, fibers, proteins, carbohydrates, nano/micro-porous scaffolds, and metals, to modulate stem cell microenvironments.

Bio-Inspired Cellular Microenvironments

Natural materials exhibit highly sophisticated properties selected by evolution to efficiently achieve specific functions. As engineers, biological scientists and physicians strive to recapitulate natural biological processes, they increasing rely on bio-inspired approaches. These strategies have been implemented in the rational design of biomedical devices and biomaterials both to influence cellular interactions with biomaterials and modulate immune response. This session covers the latest bio-inspired strategies to modulate biological responses to materials.

Biomaterials for Cardiovascular Regeneration

Cardiovascular disease is the number one cause of death globally and therefore is a major focus of regenerative engineering. Major limitations of current treatments include the lack of biomaterials with suitable chemical, physical, and biological properties, the inability to mimic tissue microarchitectures, and the availability of reliable and renewable cell sources.

Technology Development/ New Biomaterials for Immune Engineering

Biomaterial-based strategies to precisely modulate and control an immune response have emerged as a critical component in a variety of diseases and therapeutic applications. The field of immunology is relatively new as distinct discipline. As immunological principles gain clarity, biomaterial scientists are finding there are many opportunities to contribute to immunology-based therapeutics and basic discovery.

Delivery of Nucleic Acids and Other Molecules that Modulate Gene Expression

New therapeutic approaches are rapidly evolving that involve delivery of exogenous noncoding RNAs or inhibitors of endogenous micro-RNAs. This session will highly recent progress on identification of new molecular targets, therapeutic molecule design, and development of new technologies for design and delivery of siRNA, antisense, micro-RNA, and micro-RNA inhibitors (i.e., PNA, LNA, etc.). Abstracts on research at the interface of epigenetics and micro-RNA regulation are of special interest.

Local Delivery of Drugs and Growth Factors from Implant Coatings

This general session will focus on the recent advances in implant coatings for the local delivery of drugs and growth factors. The delivery of drugs locally from implant coatings reduces systemic toxicity and provides site-specific therapy. Such drug-eluting implant coatings have tremendous applications in cardiovascular devices, orthopedic and fracture fixation devices, craniofacial and dental implants, ophthalmic implants, cochlear implants, and neural devices. Growth factors are also commonly released from implant coatings for tissue engineering applications.

Targeted and Target-Activated Drug Delivery

Targeted and target-activated drug delivery systems have the potential to effectively treat a variety of medical conditions, while avoiding problems such as off-site toxicity and drug resistance. This session will focus on the design and application of targeted drug delivery systems and/or drug delivery systems whose activity is triggered by the target itself (i.e. target-activated drug delivery systems). Developing these materials while promoting an appropriate immune response and maintaining biocompatibility can be challenging.

Biologically Derived Materials from Natural Sources

Biologically derived polymers and composites offer excellent opportunities in the biomaterials field. This versatile class of materials includes biopolymers (polyhydroxy alkanoates, hyaluronic acid), polysaccharides (starch, chitin/chitosan, alginate) or proteins (collagen, fibrin, silk fibroin) enabling developing engineered systems with outstanding biological performance. The recent interest in the use of decellularized tissues as matrices for regenerative medicine offers also new avenues to use this class of materials to solve various unmet clinical needs.

Recent Advances in 3D Printing of Biomaterials

Industrial and academic researchers have recently examined the use of 3D printing technologies to overcome the limitations associated with conventional manufacturing processes. These technologies involve fabrication of three-dimensional structures through additive joining of materials in a layer-by-layer manner. This workshop will review recent developments in 3D printing technologies for processing biomaterials into artificial tissues as well as biosensors, drug delivery devices, and medical instruments.

Drug Eluting Stents and Beyond

Following angioplasty, drug eluting devices, including stents, balloons, and infusion catheters, have been shown to be effective at inhibiting restenosis resultant from vascular smooth muscle cell proliferation and neointima formation relative to non-drug eluting devices. Drug eluting stents, in particular, have yielded exceptional clinical outcomes in comparison to bare metal stents. Through an improved understanding of the mechanism by which drugs are released and intracellularly delivered, the approach used to develop second generation drug eluting devices can be improved.